Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
The Journal of frailty & aging..
Published

Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study

Authors
Kelly Virecoulon Giudici, Philipe de Souto Barreto, Christelle Cantet, Henrik Zetterberg, Kaj Blennow, Bruno Vellas, MAPT/DSA group
Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study
Nature communications
Published

Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications

Authors
Haseong Kim, Nathan J Hillson, Byung-Kwan Cho, Bong Hyun Sung, Dae-Hee Lee, Dong-Myung Kim, Min-Kyu Oh, Matthew Wook Chang, Yong-Su Jin, Susan J Rosser, Peter Vegh, Rennos Fragkoudis, Rosalind Le Feuvre, Nigel S Scrutton, Marko Storch, Wonjae Seong, Paul S Freemont, Seung-Goo Lee
Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications
Nature communications
Published

Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease

Authors
Laia Montoliu-Gaya, Shijia Bian, Eric B Dammer, Daniel Alcolea, Mathias Sauer, Mitchell Martá-Ariza, Nicholas J Ashton, Olivia Belbin, Johannes Fuchs, Caroline M Watson, Lingyan Ping, Duc M Duong, Johanna Nilsson, Isabel Barroeta, Juan Lantero-Rodriguez, Laura Videla, Bessy Benejam, Blaine R Roberts, Kaj Blennow, Nicholas T Seyfried, Allan I Levey, María Carmona-Iragui, Johan Gobom, Alberto Lleó, Thomas Wisniewski, Henrik Zetterberg, Juan Fortea, Erik C B Johnson
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease
Nature communications
Published

Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease

Authors
Francieli Rohden, Pamela C L Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano S Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Z Lussier, Douglas T Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Dana L Tudorascu, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Diogo Souza, Pedro Rosa-Neto, Tharick A Pascoal
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease
Brain : a journal of neurology
Published

Biomarker evidence of neurodegeneration in mid-life former rugby players

Authors
Neil S N Graham, Karl A Zimmerman, Jessica Hain, Erin Rooney, Ying Lee, Martina Del Giovane, Thomas Parker, Mathew G Wilson, Paresh Malhotra, Michael C B David, Magdalena Kolanko, Maneesh Patel, Elena Veleva, Owen Swann, Amanda Heslegrave, Henrik Zetterberg, Daniel Friedland, Richard Sylvester, David J Sharp
Biomarker evidence of neurodegeneration in mid-life former rugby players
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study

Authors
Vincent Malotaux, Nicholas J Ashton, Annika Öhrfelt, Yinghua Chen, Yi Su, Gloria Garcia-Ospina, Claudia Guzman-Martínez, Andres Villegas-Lanau, Johana Gómez-Ramirez, Margarita Giraldo-Chica, David Aguillon, Victoria Tirado, Ana Baena, Claudia Munoz, Natalia Acosta-Baena, Jeremy J Pruzin, Valentina Ghisays, Silvia Rios-Romenets, Clara Vila-Castelar, Jairo E Martínez, Averi Giudicessi, Pierre N Tariot, Henrik Zetterberg, Kaj Blennow, Eric M Reiman, Yakeel T Quiroz
Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study
Resuscitation
Published

Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients

Authors
Christel Pussinen, Mikko Anttonen, Lauri Wihersaari, Marjaana Tiainen, Matti Reinikainen, Johanna Hästbacka, Henrik Zetterberg, Kaj Blennow, Kari Pulkki, Markus B Skrifvars
Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients
Cancer cell
Published

Gene context drift identifies drug targets to mitigate cancer treatment resistance

Authors
Amir Jassim, Birgit V Nimmervoll, Sabrina Terranova, Erica Nathan, Linda Hu, Jessica T Taylor, Katherine E Masih, Lisa Ruff, Matilde Duarte, Elizabeth Cooper, Gunjan Katyal, Melika Akhbari, Reuben J Gilbertson, Jennifer C Coleman, Joseph S Toker, Colton Terhune, Gabriel Balmus, Stephen P Jackson, Hailong Liu, Tao Jiang, Michael D Taylor, Kui Hua, Jean E Abraham, Mariella G Filbin, Anthony Hill, Anarita Patrizi, Neil Dani, Aviv Regev, Maria K Lehtinen, Richard J Gilbertson
Gene context drift identifies drug targets to mitigate cancer treatment resistance
Brain communications
Published

The potential dual role of tau phosphorylation: plasma phosphorylated-tau217 in newborns and Alzheimer's disease

Authors
Fernando Gonzalez-Ortiz, Jakub Vávra, Emma Payne, Bjørn-Eivind Kirsebom, Ulrika Sjöbom, Cristiano Santos, Jordi Júlvez, Kaitlin Kramer, David Zalcberg, Laia Montoliu-Gaya, Michael Turton, Peter Harrison, Ann Hellström, Henrik Zetterberg, Tormod Fladby, Marc Suárez-Calvet, Robert D Sanders, Kaj Blennow
The potential dual role of tau phosphorylation: plasma phosphorylated-tau217 in newborns and Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers

Authors
Laura Stankeviciute, Núria Tort-Colet, Ana Fernández-Arcos, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Sebastian Camillo Holst, Pilar Garcés, Thomas Mueggler, Henrik Zetterberg, Kaj Blennow, Álex Iranzo, Marc Suárez-Calvet, Juan Domingo Gispert, José Luis Molinuevo, Oriol Grau-Rivera, ALFA Study
Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers
Alzheimer's & dementia (New York, N. Y.)
Published

The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline

Authors
Adam J Paulsen, Ira Driscoll, Brianne M Breidenbach, Matthew Glittenberg, Sarah R Lose, Yue Ma, Mark A Sager, Cynthia M Carlsson, Catherine L Gallagher, Bruce P Hermann, Kaj Blennow, Henrik Zetterberg, Sanjay Asthana, Sterling C Johnson, Tobey J Betthauser, Bradley T Christian, Dane B Cook, Ozioma C Okonkwo
The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
Neurology
Published

Cross-Sectional and Longitudinal Associations of Neighborhood Disadvantage With Fluid Biomarkers of Neuroinflammation and Neurodegeneration

Authors
Marissa A Gogniat, Omair A Khan, Brina Ratangee, Corey J Bolton, Panpan Zhang, Dandan Liu, Kimberly R Pechman, Alexis Yates, Leslie S Gaynor, James Eaton, Amalia Peterson, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Cross-Sectional and Longitudinal Associations of Neighborhood Disadvantage With Fluid Biomarkers of Neuroinflammation and Neurodegeneration