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Jul 03, 2025 - Research

Dementia is rare in midlife rugby players, but long-term risk may be increased

A study of 200 former professional rugby players (aged 30-61 years old), researchers from the UK DRI, Imperial College London and University College London (affiliated...

Learn more Dementia is rare in midlife rugby players, but long-term risk may be increased

Jun 13, 2025 - Research

Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

Researchers led by Dr Samuel Harris and Dr Marc Aurel Busche (UK DRI at UCL) have discovered that the amyloid precursor protein (APP) family, known...

Learn more Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

May 29, 2025 - Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life

Philos Trans R Soc Lond B Biol Sci

Published Feb 05, 2014

How environment geometry affects grid cell symmetry and what we can learn from it.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Colin Lever, John O'Keefe

How environment geometry affects grid cell symmetry and what we can learn from it.

N Engl J Med

Published Jan 23, 2014

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Authors

Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris, Marcel Reichert, Nzeera Ketter, Bijan Nejadnik, Volkmar Guenzler, Maja Miloslavsky, Daniel Wang, Yuan Lu, Julia Lull, Iulia Cristina Tudor, Enchi Liu, Michael Grundman, Eric Yuen, Ronald Black, H Robert Brashear,

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Acta Neuropathol

Published Oct 30, 2013

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Authors

Sarah Mizielinska, Tammaryn Lashley, Frances E Norona, Emma L Clayton, Charlotte E Ridler, Pietro Fratta, Adrian M Isaacs

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Nat Neurosci

Published Jul 21, 2013

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Authors

Veronique E Miron, Amanda Boyd, Jing-Wei Zhao, Tracy J Yuen, Julia M Ruckh, Jennifer L Shadrach, Peter van Wijngaarden, Amy J Wagers, Anna Williams, Robin J M Franklin, Charles Ffrench-Constant

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Brain

Published Jul 18, 2013

The role of the posterior cingulate cortex in cognition and disease.

Authors

Robert Leech, David J Sharp

The role of the posterior cingulate cortex in cognition and disease.

Nat Commun

Published May 21, 2013

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

Authors

Luke C Davies, Marcela Rosas, Stephen J Jenkins, Chia-Te Liao, Martin J Scurr, Frank Brombacher, Donald J Fraser, Judith E Allen, Simon A Jones, Philip R Taylor

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

J Cell Biol

Published Apr 15, 2013

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

Authors

Edward Avezov, Benedict C S Cross, Gabriele S Kaminski Schierle, Mikael Winters, Heather P Harding, Eduardo Pinho Melo, Clemens F Kaminski, David Ron

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

J Biol Chem

Published Jan 18, 2013

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

Authors

Jessica W Wu, Mathieu Herman, Li Liu, Sabrina Simoes, Christopher M Acker, Helen Figueroa, Joshua I Steinberg, Martin Margittai, Rakez Kayed, Chiara Zurzolo, Gilbert Di Paolo, Karen E Duff

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

N Engl J Med

Published Jan 10, 2013

TREM2 variants in Alzheimer's disease.

Authors

Rita Guerreiro, Aleksandra Wojtas, Jose Bras, Minerva Carrasquillo, Ekaterina Rogaeva, Elisa Majounie, Carlos Cruchaga, Celeste Sassi, John S K Kauwe, Steven Younkin, Lilinaz Hazrati, John Collinge, Jennifer Pocock, Tammaryn Lashley, Julie Williams, Jean-Charles Lambert, Philippe Amouyel, Alison Goate, Rosa Rademakers, Kevin Morgan, John Powell, Peter St George-Hyslop, Andrew Singleton, John Hardy,

TREM2 variants in Alzheimer's disease.

Nature

Published Dec 13, 2012

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors

Yu Ye, Georg Blaser, Mathew H Horrocks, Maria J Ruedas-Rama, Shehu Ibrahim, Alexander A Zhukov, Angel Orte, David Klenerman, Sophie E Jackson, David Komander

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Hum Mol Genet

Published Aug 01, 2012

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Authors

Gabriel Balmus, Min Zhu, Sucheta Mukherjee, Amy M Lyndaker, Kelly R Hume, Jaesung Lee, Mark L Riccio, Anthony P Reeves, Nathan B Sutter, Drew M Noden, Rachel M Peters, Robert S Weiss

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Brain

Published Jul 13, 2012

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Authors

Robert M Koffie, Tadafumi Hashimoto, Hwan-Ching Tai, Kevin R Kay, Alberto Serrano-Pozo, Daniel Joyner, Steven Hou, Katherine J Kopeikina, Matthew P Frosch, Virginia M Lee, David M Holtzman, Bradley T Hyman, Tara L Spires-Jones

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Lancet

Published Jun 23, 2012

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis.

Authors

Joanna M Wardlaw, Veronica Murray, Eivind Berge, Gregory del Zoppo, Peter Sandercock, Richard L Lindley, Geoff Cohen

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis.

PLoS One

Published Jun 14, 2012

Trans-synaptic spread of tau pathology in vivo.

Authors

Li Liu, Valerie Drouet, Jessica W Wu, Menno P Witter, Scott A Small, Catherine Clelland, Karen Duff

Trans-synaptic spread of tau pathology in vivo.

Cell

Published May 25, 2012

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Authors

Nunilo Cremades, Samuel I A Cohen, Emma Deas, Andrey Y Abramov, Allen Y Chen, Angel Orte, Massimo Sandal, Richard W Clarke, Paul Dunne, Francesco A Aprile, Carlos W Bertoncini, Nicholas W Wood, Tuomas P J Knowles, Christopher M Dobson, David Klenerman

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Nat Cell Biol

Published Apr 08, 2012

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Authors

Vincent Dion, Véronique Kalck, Chihiro Horigome, Benjamin D Towbin, Susan M Gasser

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Nat Neurosci

Published Jan 29, 2012

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Authors

Iryna Benilova, Eric Karran, Bart De Strooper

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Nat Struct Mol Biol

Published Dec 18, 2011

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

Authors

Priyanka Narayan, Angel Orte, Richard W Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A Ganzinger, Sarah Meehan, Mark R Wilson, Christopher M Dobson, David Klenerman

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.